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Conformational Changes of Corona Virus at 8.0 pH Drinking Alkaline Water

Aug, 07 2020

Conformational Changes of Corona Virus at 8.0 pH Drinking Alkaline Water
Conformational Change of the Corona virus Peplomer Glycoprotein at pH 8.0 (Potential Of Hydrogen) and 37°C Correlates with Virus Aggregation and Virus-Induced Cell Fusion

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC249489/

(JOURNAL OF VIROLOGY, American Society for Microbiology)

We have obtained biochemical and electron microscopic evidence of conformational changes at pH 8.0 and 37°C in the corona virus spike glycoprotein E2 (S). The importance of these changes is reflected in the loss of virus infectivity, the aggregation of virions, and increased virus-induced cell fusion at the same pH. Corona virus (MHV-A59) infectivity is exquisitely sensitive to pH (Potential of Hydrogen). The virus was quite stable at pH 6.0 and 37°C (half-life, -24 h) but was rapidly and irreversibly inactivated by brief treatment at pH  8.0 and 37°C (half-life, -30 min). Virions treated at pH 8.0 and 37°C formed clumps and large aggregates.

 

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